36th World Pharmacology and Therapeutics Forum scheduled during May 19-20, 2021 in Singapore city, Singapore. This Conference focusses on the theme “Exploring Novel Therapeutic Advancement in Pharmacology”. Pharma Forum 2021 is organized with an added focus on the application of pharmacological principles and quantitative methods in the real human patient's population to improve the health care.

Pharma Forum 2021 provides an optimistic platform for exchanging ideas and helps the attendees to get updated about the advancements and innovations in Pharmacology and Toxicology. The conference regular scientific sessions will be followed by exhibition, workshops and sessions of Networking.

Sessions:

• Pharmacology
• Toxicology
• Pharmacology and Drug Design
• Food and Nutritional Toxicology
• Nursing Pharmacology
• Environmental Toxicology
• Pharmacokinetics and Pharmacodynamics
• Clinical and Medical Toxicology
• Advances in Pharmacological Research
• Industrial and Occupational Toxicology
• Clinical Therapeutics
• Molecular and Biochemical Toxicology
• Clinical Pharmacology and Receptor Therapy
• Techniques in Toxicological Pathology
• Cardiovascular Pharmacology
• Molecular Pharmacology and Forensic toxicology
• Neuro and Psychopharmacology
• Pharmacotoxicology
• Ethno pharmacology and Ethno medicine
• Cognitive Behavior Therapy and Holistic Therapy

Researchers shed light on new enzymatic reaction

Researchers have discovered that repurposed enzymes and light are key to producing chemical compounds in an environmentally friendly fashion. By blending bio- and photocatalysis and experimenting with reactionary 'ingredients,' the research team developed a visible-light-induced reaction using the enzyme family ene-reductase (ER). The substrates used in this study, alkenes, can be derived in principle from biomass fatty acids; the end products are valuable chiral carbonyl compounds with potential pharmaceutical applications.

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Taking inventory of which drugs the world is using to treat COVID-19

New research catalogued every COVID treatment documented in medical literature so far and found physicians have reported on the use of more than 100 different off-label and experimental treatments.

With doctors and researchers around the world searching for effective treatments for COVID-19, many drugs approved to treat other diseases are being used in hopes that they'll be effective against the virus, a use that's known as "off-label." New research from the Perelman School of Medicine at the University of Pennsylvania catalogued every use documented in medical literature so far and found physicians have reported on the use of more than 100 different off-label and experimental treatments. The effort, called COvid19 Registry of Off-label & New Agents (CORONA), is an attempt to take an inventory of what's being used where, as well as to spot any evidence of treatments that warrant further investigation in a randomized clinical trial.

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New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue.

Chemical probes that produce a signal on magnetic resonance imaging (MRI) can be used to target and image tumors. The new research is based on a phenomenon called magnetic resonance tuning that occurs between two nanoscale magnetic elements. One acts to enhance the signal, and the other quenches it. Previous studies have shown that quenching depends on the distance between the magnetic elements. This opens new possibilities for non-invasive and sensitive investigation of a variety of biological processes by MRI.

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Story Source:

Materials provided by University of California - Davis. Original written by Andy Fell. Note: Content may be edited for style and length.

No evidence of benefit for Chloroquine and Hydroxychloroquine in COVID-19 patients, study finds

A large observational study suggests that treatment with the antimalarial drug chloroquine or its analogue hydroxychloroquine (taken with or without the antibiotics azithromycin or clarithromycin) offers no benefit for patients with COVID-19. The study analysed data from nearly 15,000 patients with COVID-19 receiving a combination of any of the four drug regimens and 81,000 controls.

Treatment with these medications among patients with COVID-19, either alone or in combination with macrolide antibiotics, was linked to an increased risk of serious heart rhythm complications in these patients.

Researchers suggest these treatment regimens should not be used to treat COVID-19 outside of clinical trials until results from randomised clinical trials are available to confirm the safety and efficacy of these medications for COVID-19 patients.

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Alzheimer's patients may need dosing changes in medicines prescribed for other conditions

Patients with Alzheimer's disease (AD) are often prescribed drugs for other conditions -- including diabetes or high blood pressure -- at the same doses as those without dementia. That practice might need to be reexamined in the wake of new mouse studies. The findings suggest that AD could alter absorption of medications from the digestive tract, so dosages might need to be adjusted for these patients.

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How stress remodels the brain

"Stress alters brain function and produces lasting changes in human behavior and physiology," Liu adds. "The experience of traumatic events can lead to neuropsychiatric disorders including anxiety, depression and drug addiction. Investigation of the neurobiology of stress can reveal how stress affects neuronal connections and hence brain function. This knowledge is necessary for developing strategies to prevent or treat these common stress-related neurological disorders."

Research has shown how stress changes the structure of the brain and reveals a potential therapeutic target to the prevent or reverse it.

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