Tuesday, February 2, 2021
Tuesday, June 9, 2020
Researchers shed light on new enzymatic reaction
Researchers have discovered that repurposed enzymes and light are key to producing chemical compounds in an environmentally friendly fashion. By blending bio- and photocatalysis and experimenting with reactionary 'ingredients,' the research team developed a visible-light-induced reaction using the enzyme family ene-reductase (ER). The substrates used in this study, alkenes, can be derived in principle from biomass fatty acids; the end products are valuable chiral carbonyl compounds with potential pharmaceutical applications.
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Wednesday, May 27, 2020
Taking inventory of which drugs the world is using to treat COVID-19
New research catalogued every COVID treatment documented in medical literature so far and found physicians have reported on the use of more than 100 different off-label and experimental treatments.
With doctors and researchers around the world searching for effective treatments for COVID-19, many drugs approved to treat other diseases are being used in hopes that they'll be effective against the virus, a use that's known as "off-label." New research from the Perelman School of Medicine at the University of Pennsylvania catalogued every use documented in medical literature so far and found physicians have reported on the use of more than 100 different off-label and experimental treatments. The effort, called COvid19 Registry of Off-label & New Agents (CORONA), is an attempt to take an inventory of what's being used where, as well as to spot any evidence of treatments that warrant further investigation in a randomized clinical trial.
at May 27, 2020
Monday, May 25, 2020
New double-contrast technique picks up small tumors on MRI
Early detection of tumors is extremely important in treating cancer. A new technique offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue.
Chemical probes that produce a signal on magnetic resonance imaging (MRI) can be used to target and image tumors. The new research is based on a phenomenon called magnetic resonance tuning that occurs between two nanoscale magnetic elements. One acts to enhance the signal, and the other quenches it. Previous studies have shown that quenching depends on the distance between the magnetic elements. This opens new possibilities for non-invasive and sensitive investigation of a variety of biological processes by MRI.
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at May 25, 2020
Sunday, May 24, 2020
No evidence of benefit for Chloroquine and Hydroxychloroquine in COVID-19 patients, study finds
A large observational study suggests that treatment with the antimalarial drug chloroquine or its analogue hydroxychloroquine (taken with or without the antibiotics azithromycin or clarithromycin) offers no benefit for patients with COVID-19. The study analysed data from nearly 15,000 patients with COVID-19 receiving a combination of any of the four drug regimens and 81,000 controls.
at May 24, 2020
Thursday, April 16, 2020
Patients with Alzheimer's disease (AD) are often prescribed drugs for other conditions -- including diabetes or high blood pressure -- at the same doses as those without dementia. That practice might need to be reexamined in the wake of new mouse studies. The findings suggest that AD could alter absorption of medications from the digestive tract, so dosages might need to be adjusted for these patients.
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